Keratinocytes within the stratum basale proliferate via mitosis and the daughter cells switch up the strata altering type and composition as they bear multiple levels of cell differentiation to finally change into anucleated. All through that process, keratinocytes will grow to be highly organized, forming cell junctions ( desmosomes ) between each other and secreting keratin proteins and lipids which contribute to the formation of an extracellular matrix and provide mechanical energy to the skin. 12 Keratinocytes from the stratum corneum are eventually shed from the floor ( desquamation ).
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